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10 Supplements to Reduce Inflammation in the Body

Inflammation is the main part of your body’s immune response, with the purpose of protecting against harmful stimuli and initiating the healing process. However, when inflammation becomes chronic, it results in various health issues. Many people seek supplements to reduce inflammation in the body, aiming to support their overall health and well-being. If you are one of them, dive into this guide.

Supplements to Reduce Inflammation in the Body

Anti-inflammatory supplements target pathways involved in the inflammatory response. They often contain natural compounds known for their anti-inflammatory properties. These supplements may modulate the production of inflammatory mediators, such as cytokines and prostaglandins. Some supplements also act as antioxidants, opposing free radicals and reducing oxidative stress, which often contributes to inflammation. While research on certain supplements is still ongoing, many people incorporate them into their daily routine to support overall health and reduce the risk of chronic inflammatory conditions.

In order to help you choose the best supplements to reduce inflammation, we created a comprehensive list of the most potent ones. Enjoy!


Resveratrol is a natural compound found in certain plants, particularly red grapes, peanuts, and berries. It is known for its remarkable anti-inflammatory effects, which are attributed to its ability to modulate various inflammatory pathways in the body. Resveratrol inhibits the production of inflammatory mediators such as cytokines and prostaglandins. It also acts as an antioxidant, neutralizing free radicals and reducing oxidative stress. Additionally, resveratrol may improve the function of mitochondria (the energy-producing organelles in cells), which have a positive impact on inflammation and overall cellular health


Quercetin is a flavonoid found in many fruits and vegetables with strong antioxidant and anti-inflammatory properties. It reduces inflammation by inhibiting the production and release of inflammatory mediators such as histamine, cytokines, and prostaglandins. Quercetin also regulates the activity of enzymes involved in inflammatory pathways, which further contributes to its anti-inflammatory effects. Certain studies suggest that quercetin may modulate immune cell activity, helping to balance the immune response and reduce excessive inflammation. 


Curcumin is the bioactive compound found in turmeric, a popular spice known for its bright yellow color and use in traditional Indian medicine. Curcumin is renowned for its potent anti-inflammatory properties, which stem from its ability to inhibit various molecules that participate in inflammation. It blocks the activity of the enzymes cyclooxygenase-2 (COX-2) and lipoxygenase, which are involved in the synthesis of prostaglandins and leukotrienes. Apart from this, curcumin suppresses the production of inflammatory cytokines and chemokines and acts as a potent antioxidant. 

Vitamin E

Vitamin E is a fat-soluble vitamin and a powerful antioxidant that protects cells from oxidative damage. It also helps regulate the immune response and may reduce the production of pro-inflammatory cytokines. By reducing oxidative stress and modulating immune function, vitamin E can help combat inflammation and reduce the risk of chronic inflammatory conditions. However, it’s important to note that while vitamin E supplementation may be beneficial for some individuals, excessive intake can have adverse effects, so it’s best to obtain vitamin E from a healthy diet based on eggs, fresh vegetables, nuts, and seeds.

Omega-3 Fatty Acids

Omega-3 fatty acids are a group of polyunsaturated fats that are essential for human health. They are primarily found in fatty fish like salmon, sardines, and mackerel, as well as in certain plant sources such as flaxseeds and walnuts. Omega-3 fatty acids are well-known for their anti-inflammatory properties, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These fatty acids compete with pro-inflammatory omega-6 fatty acids in the body, which results in the synthesis of fewer inflammatory molecules.

Vitamin D

Vitamin D, or “sunshine vitamin,” is also a fat-soluble vitamin that is responsible for calcium absorption and bone health. However, emerging research suggests that vitamin D also has anti-inflammatory effects. Vitamin D modulates the immune system by regulating the production and activity of immune cells and cytokines involved in the inflammatory response. It has been shown to suppress pro-inflammatory cytokines while promoting anti-inflammatory cytokines, maintain immune balance, and reduce excessive inflammation. Maintaining optimal vitamin D levels through sunlight exposure, diet, or supplements may support overall health and reduce the risk of inflammatory diseases.

Vitamin C

Vitamin C, also known as ascorbic acid, is a water-soluble vitamin noted for its immune-boosting properties and skin-health benefits. It also exhibits anti-inflammatory properties, primarily through its antioxidant activity. As an antioxidant, vitamin C scavenges free radicals that cause inflammation. In this way, vitamin C reduces oxidative damage and inflammation in the body. On the other hand, vitamin C is involved in the synthesis of collagen, a protein responsible for wound healing and maintaining the integrity of the skin and connective tissues. 


Zinc is an essential mineral that is involved in various physiological processes, notably immune function and wound healing. It has strong anti-inflammatory effects that stem from its ability to modulate the immune response. The important function of this mineral is to regulate the activity of immune cells, such as T lymphocytes, which are the main agents for responding to infection and inflammation. Zinc also regulates inflammatory signaling pathways, which helps to balance the inflammatory response and prevent chronic inflammation.


Magnesium is a mineral that is necessary for energy production, muscle function, and bone health. It is thought that magnesium may help combat inflammation by modulating immune responses and reducing the production of cytokines. Magnesium also acts as a cofactor for enzymes involved in antioxidant defense, helping to reduce oxidative stress and inflammation. Magnesium deficiency has been associated with chronic, low-grade inflammation. 

Methylsulfonylmethane (MSM)

MSM is a naturally occurring compound found in plants, animals, and humans. It is considered the best supplement for pain and inflammation associated with various conditions, such as arthritis and exercise-induced muscle damage. MSM’s sulfur component is primarily responsible for its anti-inflammatory properties. Sulfur is an essential component of many proteins and enzymes involved in the inflammatory process. 


Frequently Asked Questions


What is the most powerful supplement for inflammation?

Polyphenols are regarded as the most powerful supplements for inflammation due to their diverse mechanisms of action. These compounds can modulate inflammatory signaling pathways, inhibiting the production of pro-inflammatory cytokines and enzymes while promoting the expression of anti-inflammatory mediators. Some polyphenols also interact with the gut microbiota, promoting a healthy gut microbiome that hinders systemic inflammation. Certain polyphenols may also inhibit the activation of inflammatory cells, which enhances their anti-inflammatory properties.


What is the strongest anti-inflammatory herb?

One of the strongest anti-inflammatory herbs is ginger, known for its potent anti-inflammatory and antioxidant properties. Ginger contains bioactive compounds like gingerol, which inhibit the production of pro-inflammatory cytokines and enzymes. Studies have demonstrated that ginger can reduce inflammation in conditions such as osteoarthritis, rheumatoid arthritis, and inflammatory bowel disease. Additionally, ginger may alleviate muscle soreness and reduce post-exercise inflammation. Including ginger in your diet or consuming ginger supplements may provide anti-inflammatory benefits and support overall health.